Mito Uzumaki

Mito Uzumaki was a kunoichi who originated from Uzushiogakure's Uzumaki clan and later married into Konohagakure's Senju clan. She was also the first jinchūriki of Kurama the Nine-Tailed Demon Fox.

Manga Debut: Chapter #500
Anime Debut: Naruto Shippuuden Episode #247

(source: Narutopedia)