Saigo no Ω wa Tsugai ni Narenai

There was a widespread virus that could only infect Omegas. There was only one Omega who had survived in the whole world, an Omega that had natural antibodies against the virus, Shuu Miyamoto. He was then isolated by a government research institution and was forced to have children with Alphas. However, the Alpha who was chosen one day, Honda, was different from anyone else so far as Shuu went into heat the moment their eyes met...! Honda, who was following his natural instincts as an Alpha, and Shuu, who was drowning in lust. Even though Shuu knew this person in front of him was his fated partner, the relationship between these two, who could not become partners for life is...

(Source: Core Magazine, translated)